TLR3 激动剂（CD283）及相关产品介绍
TLR3(又名CD283)是一个胞内受体，可识别与病毒感染相关的双链RNA(dsRNA)分子模式。其中一个TLR3的配体，Poly(I:C)，是人工合成的dsRNA类似物。TLR3信号通路不依赖于MyD88，而是通过接头蛋白TRIF(包含TIR结构域的接头蛋白，可诱导IFN-β产生)发挥作用。IRF3(干扰素调节因子3)被磷酸化后导致IFN-β(β干扰素)产生，进一步活化ISRE(干扰素激活反应元件)。另外，TLR3信号通路的激活也可导致AP-1和NF-kB等转录因子入核，促进一些炎症因子的释放。
TLR3激动剂相关产品：
|
PRODUCT |
ORIGIN/DESCRIPTION |
GRADE* |
WORKING CONCENTRATION |
QTY |
CATALOG CODE |
|
TLR LIGANDS |
|||||
|
TLR3 Agonists |
|||||
|
Poly(A:U) |
Polyadenylic-polyuridylic acid |
TLR2 -/ TLR4 – |
300 ng- 100 µg/ml |
10 mg |
tlrl-pau |
|
Poly(I:C) (HMW) |
Polyinosine-polycytidylic acid High molecular weight (1.5-8 kb) |
TLR2 -/ TLR4 – |
30 ng – 10 µg/ml |
10 mg 50 mg |
tlrl-pic tlrl-pic-5 |
|
Poly(I:C) (HMW) Biotin |
Biotinylated poly(I:C) (HMW) |
TLR2 -/ TLR4 – |
30 ng – 10 µg/ml |
10 µg |
tlrl-picb |
|
Poly(I:C) (HMW) Fluorescein |
Fluorescein-labeled poly(I:C) (HMW) |
TLR2 -/ TLR4 – |
10 ng – 10 µg/ml |
10 µg |
tlrl-picf |
|
Poly(I:C) (HMW) Rhodamine |
Rhodamine-labeled poly(I:C) (HMW) |
TLR2 -/ TLR4 – |
10 ng – 10 µg/ml |
10 µg |
tlrl-picr |
PRR Ligands
|
PRODUCT |
ORIGIN/DESCRIPTION |
GRADE* |
WORKING CONCENTRATION |
QTY |
CATALOG CODE |
|
TLR3 Agonists |
|||||
|
Poly(I:C) (HMW) VacciGrade™ |
Preclinical grade poly(I:C) (HMW) |
VacciGrade™ |
10 µg – 100 µg/mouse |
10 mg |
vac-pic |
|
Poly(I:C) (LMW) |
Polyinosine-polycytidylic acid Low molecular weight (0.2-1 kb) |
TLR2 – /TLR4 – |
30 ng – 10 µg/ml |
25 mg 250 mg |
tlrl-picw tlrl-picw-250 |
|
Poly(I:C) (LMW) Rhodamine |
Rhodamine-labeled poly(I:C) (LMW) |
TLR2 – /TLR4 – |
100 ng – 10 µg/ml |
10 µg |
tlrl-piwr |
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