GSK2606414CAS号： 1337531-36-8分子式： C24H20F3N5O分子量： 451.44描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
GSK2606414; GSK-2606414
|
| 外观 |
白色粉末
|
| 可溶性/溶解性 |
DMSO : 45.1 mg/mL (100 mM)
|
| 生物活性 | |
| 靶点 |
eIF-2AK1 (HRI)；eIF-2AK2 (PKR)；eIF-2AK3 (PERK)
|
| In vitro(体外研究) |
GSK2606414 inhibits PERK activation in cells.
|
| In vivo(体内研究) |
GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice.
|
分子结构图
