Purified Rabbit Polyclonal Antibody (Pab)

ZNF281抗体;Zinc finger protein 281; GC-box-binding zinc finger protein 1; Transcription factor ZBP-99; Zinc finger DNA-binding protein 99; ZNF281; GZP1; ZBP99

Rabbit

This ZNF281 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 416-450 amino acids from the Central region of human ZNF281.

Human, Mouse

WB~~1:1000

Predicted molecular weight: 97kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Polyclonal Antibody

Rabbit Ig

Maintain refrigerated at 2-8°C for up to 2 weeks. For long time storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Developmental Biology;Signal Transduction;Stem Cells

Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G- rich box in the enhancer region of these genes.

Nucleus.

Q9Y2X9

Law D.J.,et al.Biochem. Biophys. Res. Commun. 262:113-120(1999).
Lisowsky T.,et al.FEBS Lett. 453:369-374(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Zhang X.,et al.Nucleic Acids Res. 31:2900-2914(2003).